In Vitro & In Vivo Screening

Clinvet offers various in vitro and in vivo screening models in our laboratories. Several new techniques have been developed and have greatly expanded the application of these principles. Other than reducing the burden on the test compound, these screening methods provide simple and more convenient methods, faster results, reduced use of animals and a lower cost.

In vitro assays include contact and repellency bioassays, as well as artificial feeding models and systems. The former two use direct exposure of the parasites to an active ingredient, either in solution or on filter paper, glass or other materials. In artificial feeding assays, systemic compounds can be tested by allowing ectoparasites to feed on treated blood or another media across an artificial membrane or by allowing endoparasites to move through a medium and assessing behavior.

In vitro assays against ectoparasites include contact (LPT, LIT, AIT, etc) and membrane feeding assays covering various companion and production animal ticks in addition to membrane feeding assays for flies and mosquitoes.

Small animal models against ticks and fleas are also feasible. Against endoparasites, various in vitro motility and development assays are offered, as well as dual infection, small animal models.